Molecular Biological Markers for Toxicology and Risk Assessment 1st Edition Bruce 0128019018 9780128019016

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Product details:

• ISBN 10: 0128019018
• ISBN 13: 9780128019016
• Author: Bruce A. Fowler

Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity.

Table of contents:

Chapter 1: Molecular Biological Markers for Toxicology and Risk Assessment

Abstract

1. Introduction

2. Enzyme Activity–Based Biomarkers

3. Currently Measured Biomarker Proteins

4. Omic Biomarkers

5. Computational Toxicology Approaches

6. Application of Molecular Biomarkers for Risk Assessment

Chapter 2: Historical Development of Biomarkers

Abstract

1. Biomarkers of Exposure

2. Exposome and Biomarkers of Exposure

3. Specific Biomonitoring Analytical Methodologies

4. Biomonitoring Studies

5. Biological Monitoring for Chemical Metabolites and Interconverted Chemical Species

6. Clinical Biomarkers—Current Usages and Prospects for the Future

7. Biomarker Modifying Factors and Identification of Populations at Risk

8. Technical Advances in Instrumentation

9. Basic Scientific Biomarker Validation Approaches

Chapter 3: Computational Toxicology

Abstract

1. Introduction

2. Data Mining Approaches—Getting an Overview of the Current Molecular Biomarker Literature

3. Some Useful and Publically Available Data Resources

4. International Public Health Databases

5. European Union

6. Chemical Risk Assessment Resources in Selected Countries and States

7. WHO Chemical Risk Assessment Network

8. Computational Toxicology Approaches to Biomarker Development and Validation

9. Toxicology Testing Resources in Europe

10. Computational Tools for Capturing the Biomarker Literature

11. Computational Approaches for Assisting in Molecular Biomarker Development

12. Applications of Computational Methods for Guiding Biological Marker Research—A Summary

Chapter 4: Omic Biological Markers

Abstract

1. Introduction

2. Statistical/Bayesian Approaches for Delineating Biomarkers

3. Proteomics

4. Metabolomics/Metabonomics

5. Current Applications of Omic Biomarkers for Risk Assessment Purposes

Chapter 5: Validation of Biological Markers for Epidemiological Studies

Abstract

1. Introduction

2. Molecular Biomarker Validation Through Correlation With Other Biological Endpoints

3. Application of Computational Modeling Approaches for Extrapolating From In Vitro or Experimental Animal Model Systems for Molecular Biomarker Validations

4. Ease of Application for Risk Assessment Practice

5. Correlations at the Population Level and Population-Based Risk Assessment Studies via NHANES

6. Applications to Risk Assessment Practice

Chapter 6: Technical Translational Analysis of Molecular Biomarker Data

Abstract

1. Introduction

2. Modeling and Interpretation of Data

3. Integration of Diverse Data Sets

4. Validation of Biological Marker Data With Other Outcome Data

Chapter 7: Quality Assurance/Quality Control (QA/QC) for Biomarker Data Sets

Abstract

1. Introduction

2. General Definitions

3. Discussion of QA/QC Definition

4. Sample Handling for Biomarker Development

5. Intrinsic Variability of Measured Biomarker Endpoints

6. Equipment Maintenance, Internal Standards, and Chain of Custody for Assurance of Data Quality

7. Data Analysis and Archival Storage Needs

8. Summary and Conclusions

Chapter 8: Translation of Biomarkers for Human Clinical and Epidemiological Studies

Abstract

1. Introduction

2. Clear Definitions of Biomarker Terminology

3. Biomarkers for Epidemiological Studies

4. Biomarkers for Chemical Mixture Risk Assessments

5. Merging Chemical Exposure Data and Genetic Inheritance Data for Risk Assessments

6. Summary and Conclusions

Chapter 9: Risk Communication of Molecular Biomarker Information

Abstract

1. Introduction

2. Information Mapping Technology

3. Translation of Molecular Biomarker Data for Societal Decision Making

4. Summary and Conclusions

Chapter 10: Future Research Directions

Abstract

1. Further Validation of Biological Markers for Humans and Barriers to Acceptance Into Risk Acceptance Practice

2. Application of Artificial Intelligence Computer Programs for Integrating Diverse Data Sets and Facilitating Risk Assessments

3. Calculation of Acceptable Exposure Levels for Chemicals on an Individual or Mixture Basis

4. Incorporation of Individual Genotypes Into Biological Marker-Based Risk Assessments

5. Getting on the Rising Road—Some Suggestions

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