Naturally Occurring Chemicals Against Alzheimer’s Disease 1st edition by Tarun Belwal, Seyed Mohammad Nabavi, Seyed Fazel Nabavi, Ahmad Reza Dehpour, Samira Shirooie ISBN 0128192135 9780128192139

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ISBN 10:      0128192135
ISBN 13: 978-0128192139
Author:      Tarun Belwal, Seyed Mohammad Nabavi PhD, Seyed Fazel Nabavi, Ahmad Reza Dehpour, Samira Shirooie

Naturally Occurring Chemicals Against Alzheimer’s Disease 1st Table of contents:

Chapter 1. Introduction

• Introduction

Chapter 2. Alzheimer’s Disease: Ethanobotanical Studies

• Introduction
• Medicinal Plants Used Against Alzheimer’s Disease (AD)
• Gaps and Future Challenges
• Conclusions
• Phytochemicals/Plant Extracts Against Alzheimer’s Disease

Section 3.1. Phytochemicals (Pure Compounds)

Chapter 3.1.1. Resveratrol

• Introduction
• Sources
  • Natural Sources
• Pharmacokinetics
• Chemistry
• Resveratrol in Alzheimer’s Disease
• Toxicology and Adverse Drug Reactions
• Clinical Trials

Chapter 3.1.2. Curcumin

• Introduction
• Alzheimer’s Disease: Symptoms and Pathophysiology
• Phytomedicinal Properties of Curcumin in Relation to Alzheimer’s Disease
• Role of Curcumin in Clinical Studies/Trials
• Impact of Curcumin on Alzheimer’s Disease
• Treatment of Alzheimer’s Disease
• Conclusion

Chapter 3.1.3. Omega-3 Polyunsaturated Fatty Acids (PUFAs)

• Introduction
• Alzheimer’s Disease
• Why Omega-3?
• Importance of Omega-3
• Clinical Trials
• Conclusion

Chapter 3.1.4. Galantamine

• Introduction
• Biological and Geographical Distribution
• In Vitro Production of Galantamine
• Chemistry
• Pharmacology
• Galantamine in Alzheimer’s Disease
• Toxicology and Adverse Drug Reactions
• Conclusion

Chapter 3.1.5. Rivastigmine

• Introduction
• Rivastigmine
• Available Dosage Forms of Rivastigmine
• Tolerability
• Conclusion

Chapter 3.1.6. Quercetin

• Introduction
• Quercetin and Its Pharmacological Properties
• Conclusion

Chapter 3.1.7. Valerenic and Acetoxyvalerenic Acid

• Introduction
• Occurrence
• Chemical Structure
• Pharmacological Potential of Valerenic Acid and Acetoxyvalerenic Acid
• Clinical Studies
• Conclusion

Chapter 3.1.8. Huperzine A

• Introduction
• Chemistry of Huperzine A
• Conclusions

Chapter 3.1.9. Caprylic/Capric Triglyceride

• Introduction
• Synthesis and Chemistry of Caprylic Triglyceride
• Properties of Capric Triglyceride
• Uses of Capric Triglyceride
• Alzheimer’s Disease and Capric Triglyceride-Based Medical Food
• Mechanism of Action and Biochemistry
• Case Studies Related to Caprylic Triglyceride-Based Treatment in Alzheimer’s Disease
• Precautionary Advice
• Conclusion

Chapter 3.1.10. Berberine

• Introduction
• Berberine and Its Pharmacological Properties
• Side Effects and Toxicological Profile of Berberine (BBR)
• Conclusion

Chapter 3.1.11. Hypericin and Pseudohypericin

• Introduction
• Description of Hypericum perforatum L.
• Bioactive Constituents
• Pharmacological Activities of HP
• Safety
• Conclusion

Chapter 3.1.12. Protopine

• Introduction
• Synthesis of Protopine
• Crystal Structure of Protopine Hydrochloride (Salt of Protopine)
• Biological Activities of Protopine
• Other Pharmacological Activity
• Antioxidant and Anticancer Activity
• Concluding Remarks

Chapter 3.1.13. Spinosin

• Introduction
• Causes and Mechanism of Alzheimer’s Disease
• Diagnosis of Alzheimer’s Disease
• Current Therapies for Alzheimer’s Disease
• Spinosin
• Potential of Spinosin Against Alzheimer’s Disease
• Future Directions and Conclusion

Chapter 3.1.14. Nobiletin

• Introduction
• Chemistry and Sources of Nobiletin
• Metabolism and Distribution in the Human Body
• Pharmacological Effects of Nobiletin in the Prevention and Treatment of AD
• Studies in Humans
• Conclusions

Section 3.2. Plants and Their Extracts

Chapter 3.2.1. Ginkgo biloba

• Introduction
• Alzheimer’s Disease
• Major Constituents of Ginkgo Biloba and Their Modes of Action
• Antioxidant Activity
• Protective Effects on Mitochondrial Function
• Antiapoptotic Effect
• Antiinflammatory Effect
• Preventive Effects on Amyloidogenesis and Aβ Aggregation
• Some Other Mechanisms
• Possible Mechanism of Actions
• Conclusion

Chapter 3.2.2. Panax Ginseng C.A. Meyer

• Introduction
• Taxonomy and Distribution
• Bioactive Constituents
• Mechanism of Action
• Pharmacological Studies
• Dosage
• Side Effects
• Conclusion and Recommendations

Chapter 3.2.3. Melissa officinalis (Lemon Balm)

• Introduction
• Taxonomy
• Cultivation
• Phytochemical Profile
• Traditional Uses and Pharmacology
• Treatment
• Mechanism of Action
• Safety
• Conclusion

Chapter 3.2.4. Bacopa monnieri (Brahmi)

• Introduction
• Taxonomical Classification of B. Monnieri
• Mechanism of Action of B. Monnieri in Alzheimer’s Disease (AD)
• Experiments on B. Monnieri Related to Alzheimer’s Disease (AD) Using In Vitro and In Vivo Methods
• Clinical Studies on B. Monnieri with Respect to Alzheimer’s Disease (AD)
• Adverse Effects Associated with B. Monnieri
• Conclusion

Chapter 3.2.5. Centella Asiatica

• Introduction
• Alzheimer’s Disease
• In Vitro and In Vivo Studies
• Clinical Studies
• Conclusion

Chapter 3.2.6. Rosmarinus officinalis L. (Rosemary)

• Introduction, Botanical Description, and Distribution
• Bioactive Compounds
• Rosemary–Drug Interactions
• Impact of Rosemary on Diseases of the Central Nervous System
• Side Effects
• Conclusion

Chapter 3.2.7. Valeriana officinalis (Valerian)

• Introduction
• Valeriana Officinalis and Alzheimer’s Disease
• Conclusion

Chapter 3.2.8. Matricaria recutita (Chamomile)

• Introduction
• M. Recutita L.
• Conclusion

Chapter 3.2.9. Galanthus nivalis L. (Snowdrop)

• Background
• Distribution and Habitat Associated with Galanthus Nivalis
• Botany of Galanthus Nivalis
• Phytochemistry and Structure–Activity Relationship
• Importance of Snowdrops in Neurodegenerative Disorders
• Clinical Studies on Galanthus Nivalis with Respect to Alzheimer’s Disease
• Conclusion

Chapter 3.2.10. Guggulu [Commiphora wightii (Arn.) Bhandari]

• Introduction
• Pathophysiology of Alzheimer’s Disease (AD)
• Antioxidants and Alzheimer’s Disease
• Guggulu (Commiphora Wightii)
• Chemistry
• Antioxidant and Anti-inflammatory Activity (Preclinical and Clinical Studies)
• Mechanism of Action
• Safety Issues
• Drug Interactions
• Conclusion

Chapter 3.2.11. Lepidium meyenii (Maca)

• Introduction
• Chemical Composition of Maca
• Mechanism of Action and Pharmacological Actions of Lepidium Meyenii
• Clinical Studies of Lepidium Meyenii
• Toxicity Profile of Lepidium Meyenii
• Conclusion

Chapter 3.2.12. Acorus calamus

• Introduction
• Phytochemical Investigation of Acorus Calamus L.
• Pharmacology of Acorus Calamus L.
• Cognitive Impairment
• Cholinergic System and Cognitive Impairment: Mechanism of Action
• Clinical Trials and Safety Issues Related to Acorus Calamus in AD
• Role of Acorus Calamus in AD
• Conclusion

Chapter 3.2.13. Tinospora cordifolia

• Plants and Their Extracts

Chapter 3.2.14. Magnolia officinalis

• Alzheimer’s Disease and Treatment Approaches
• **Magnolia Officinalis Re

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