Parkinson’s Disease Therapeutics Emphasis on Nanotechnological Advances 1st Edition by Magisetty Obulesu 0128198834 9780128198834

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ISBN-10 :  0128198834 

ISBN-13 :  9780128198834

Author:  Magisetty Obulesu 

Parkinson’s Disease Therapeutics: Emphasis on Nanotechnological Advances presents the latest information on the second most common neurodegenerative disorder in the elderly. Despite remarkable progress in various PD therapeutics, such as microRNAs and brain drug delivery systems, a few limitations impede their success. This book sheds light on the pros and cons of recently developed novel therapeutics. Very few books have highlighted the protective efficacy of natural products, antioxidants, and biomaterial design for other diseases.

Parkinson’s Disease Therapeutics: Emphasis on Nanotechnological Advances 1st Table of contents:

Chapter 1. Introduction: Parkinson’s disease pathology and therapeutics
1. Introduction
2. Micro-ribonucleic acid
3. Drugs
4. Viral vectors
5. Conclusions and future perspectives
Chapter 2. Biomaterials: a boon or a bane in the treatment of Parkinson’s disease
1. Introduction
2. Oxidative stress
3. Nanoparticles
4. Neurturin
5. Delivery systems for natural compounds
6. Diagnosis
7. Silver nanoparticles
8. Immunotherapy
9. Shortcomings of nanotechnology
10. Conclusions and future perspectives
Chapter 3. Blood–brain barrier targeted nanoparticles
1. Introduction
2. Blood–brain barrier impairment
3. Blood–brain barrier spanning of nanoparticles
4. Parkinson’s disease
5. Nanoparticles for Parkinson’s disease
6. Gold nanoparticles
7. Quercetin nanoparticles
8. Conclusions and future perspectives
Chapter 4. Natural compounds in the treatment of Parkinson’s disease
1. Introduction
2. Plant-derived compounds
3. Amelioration of antioxidant enzymes
4. Conclusions and future perspectives
Chapter 5. Curcumin: a promising therapeutic in Parkinson’s disease treatment
1. Introduction
2. Antioxidant activity
3. 6-Hydroxydopamine and MPTP PD models
4. α-Synuclein targeting
5. Curcumin derivatives
6. Bioavailability
7. Heat shock proteins
8. Antiapoptosis
9. Metal chelation
10. Delivery systems for curcumin
11. Conclusions and future perspectives
Chapter 6. Redox nanoparticles: the corner stones in the development of Parkinson’s disease therapeutics
1. Introduction
2. Parkinson’s disease diagnosis
3. Coenzyme Q10
4. Conclusions and future perspectives
Chapter 7. Liposomal maneuvers against Parkinson’s disease
1. Introduction
2. Blood–Brain Barrier
3. Liposomes
4. Surface functionalization in brain targeting
5. Demerits of liposomes
6. Conclusions and future perspectives
Chapter 8. Nasal delivery nanoparticles: An insight into novel Parkinson’s disease therapeutics
1. Introduction
2. Nasal delivery
3. Challenges in nasal delivery
4. Demerits of nose to brain delivery
5. Conclusions and future perspectives
Chapter 9. α-Synuclein-targeted nanoparticles
1. Introduction
2. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment
3. Fibrillation
4. Early diagnosis
5. Conclusions and future perspectives
Chapter 10. Pros and cons of Parkinson’s disease therapeutics
1. Introduction
2. α-Synuclein
3. Caenorhabditis elegans: a potential animal model for Parkinson’s disease
4. Blood–brain barrier
5. Stem cell therapy
6. Influence of gut microbiota on neurodegenerative diseases
7. Conclusions and future perspectives

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Tags: Parkinson’s Disease, Therapeutics, Emphasis, Nanotechnological Advances, Magisetty Obulesu