Pathology for Toxicologists Principles and Practices of Laboratory Animal Pathology for Study Personnel 1st Edition by Elizabeth Mcinnes ISBN 1118755413 978-1118755419

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Product details:

ISBN 10: 1118755413 

ISBN 13: 978-1118755419

Author: Elizabeth Mcinnes

Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important  to the pharmaceutical company or whether the lesions are background changes and thus of little significance.

Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound.

This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of their training or career who want to know more about the pathology encountered in laboratory animals used in safety studies.  Key features include important chapters on  spontaneous and target organ lesions in rats, mice, non-human primates, mini pigs, rabbits and beagle dogs as well as information on general pathology, macroscopic target organ lesions, ancillary pathology techniques, haematology, biochemistry and adversity.

Table of contents: 

Chapter 1: An Introduction to Pathology Techniques

1.1 Animal Considerations
1.2 Necropsy
1.3 Lung Inflation with Fixative
1.4 Fixation
1.5 Making Glass Slides
1.6 Special Histochemical Stains
1.7 Decalcification
1.8 Immunohistochemistry
1.9 Tissue Crossreactivity Studies
1.10 Electron Microscopy
1.11 In Situ Hybridisation
1.12 Laser Capture Microscopy
1.13 Confocal Microscopy
1.14 Image Analysis
1.15 Digital Imaging
1.16 Spermatocyte Analysis
1.17 Good Laboratory Practice
1.18 Inhalation Studies
1.19 Continuous-Infusion Studies
1.20 Carcinogenicity
1.21 Biologicals
1.22 The Pathology Report
1.23 Conclusion

Chapter 2: Recording Pathology Data

2.1 What is a Pathology Finding?
2.2 Standardisation of Pathology Findings
2.3 ‘Inconsistencies’ in Pathology Recording
2.4 Blind Review
2.5 Historical Control Data: Pros and Cons
2.6 The Use of Peer Review in Pathology

Chapter 3: General Pathology and the Terminology of Basic Pathology

3.1 Cellular Responses to Insults
3.2 Inflammation
3.3 Circulatory Disturbances
3.4 Disorders of Tissue Growth
3.5 Tissue Repair and Healing
3.6 Neoplasia
3.7 Immune System

Chapter 4: Common Spontaneous and Background Lesions in Laboratory Animals

4.1 Rats
4.2 Mice
4.3 Dogs
4.4 Minipigs
4.5 Non-Human Primates
4.6 Rabbits
4.7 Experimental Procedures
4.8 Causes of Death in Rats and Mice
4.9 Conclusion

Chapter 5: Target Organ Pathology

5.1 Skin
5.2 Eye
5.3 Gastrointestinal Tract
5.4 Liver
5.5 Respiratory System
5.6 Urinary System
5.7 Lymphoreticular System
5.8 Musculoskeletal System
5.9 Cardiovascular System
5.10 Endocrine System
5.11 Reproductive System
5.12 Central and Peripheral Nervous System
5.13 Ear

Chapter 6: Clinical Pathology

6.1 Clinical Pathology in Study Phases and Good Laboratory Practice
6.2 What is Measured in Clinical Pathology?
6.3 Haematology
6.4 Coagulation
6.5 Clinical Chemistry
6.6 Urinalysis
6.7 Acute-Phase Proteins
6.8 The Biomarker Concept
6.9 Reference Intervals
6.10 Instrumentation, Validation and Quality Control
6.11 Data Analysis and Interpretation
6.12 Reporting
6.13 Food Consumption and Body Weight (Gain)
6.14 Organ Weights
6.15 Examples of Typical Clinical Pathology Profile Changes in Toxicologic Clinical Pathology
6.16 Microsampling
6.17 Conclusion

Chapter 7: Adversity: A Pathologist’s Perspective

7.1 LOAEL, NOEL and NOAEL: Definition
7.2 Adversity
7.3 Determining Adversity using Pathology Findings: Factors to Consider
7.4 Communicating NOAEL in Toxicity Studies
7.5 Conclusion

Chapter 8: Limitations of Pathology and Animal Models

8.1 Limitations of In Vivo Animal Models
8.2 Efficacy/Disease Models as Toxicology Models
8.3 Limitations of Efficacy/Disease Models as Toxicology Models
8.4 Limitations of Pathology within In Vivo Toxicology Models
8.5 Managing Risk Associated with Subjectivity and the Potential for Pathologist Error

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Elizabeth Mcinnes,Pathology,Toxicologists Principles,Laboratory Animal Pathology,Study Personnel