Personalized Anaesthesia Targeting Physiological Systems for Optimal Effect 1st Edition by Pedro L Gambús, Jan F A Hendrickx ISBN 1107579252 978-1107579255

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Product details:

ISBN 10: 1107579252

ISBN 13:  978-1107579255

Author: Pedro L. Gambús, Jan F. A. Hendrickx

Personalized Anaesthesia presents a modern vision of anaesthesia. Integrating technology and knowledge from leading experts in the field, this book will change the way anaesthesia is both taught and practiced. Modern practice requires the anaesthetist to provide patient-specific management. This is the first resource to be organised by the desired physiological effect, rather than by drug groupings, explaining how physiological changes can be produced and controlled according to the characteristics of each patient and the particular surgical context. The book integrates physiology, pharmacology and technology, and applies these concepts in a systematic manner to each homeostatic system. This will optimise drug titration, effect quantification and decision making in anaesthesia practice to match the needs of the individual patient. Complex mathematical and scientific concepts are explained using accessible text, colour illustrations throughout and graphs. This is an essential text for any consultant or trainee working in anaesthesia.

Table of contents: 

Section 1 – Basic Principles

1. Principles of Quantitative Clinical Pharmacology
2. Pharmacokinetic and Pharmacodynamic Modelling in Anaesthesia
3. Drug Interactions: Additivity and Synergy among Anaesthetic Drugs
4. Covariate Analysis in Clinical Anaesthesia
5. Signal Analysis and Response Measurement
6. Application of Pharmacokinetics and Pharmacodynamics and Signal Analysis to Drug Administration in Anaesthesia

Section 2 – Targeting Effects

7. Hypnotic Effect: Inducing Unconsciousness and Emergence from Anaesthesia
8. Analgesia: Effects on Response to Nociceptive Stimulation
9. Personalized Sedation and Analgesia
10. Respiratory Depression
11. Immobility
12. Effects on Brain Function
13. Targeted and Individualized Perioperative Medicine for Cognitive Dysfunction
14. Cardiac and Haemodynamic Function
15. Effects of Anaesthesia on Thermoregulation
16. Effects of Perioperative Management on Kidney Function
17. Effects on Liver Function
18. Effects on Fluid Balance
19. Ventilation during General Anaesthesia
20. Epilogue: Artificial Intelligence Methods

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