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Product details:
- ISBN 10: 0128178914
- ISBN 13: 9780128178911
- Author: Chukwuebuka Egbuna
Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases.
Table of contents:
Part I. Plants as natural sources of drugs
Chapter 1. Plant secondary metabolites as lead compounds for the production of potent drugs
Chapter 2. Factors affecting the choice for plant-based products in drug discoveries
Chapter 3. Advances in computer-aided drug discovery
Chapter 4. FDA drug candidacy acceptance criteria and steps: problems and way forward
Part II. Biofunctional leads for drug development
Chapter 5. Bioactive lead compounds and molecular targets for the treatment of heart diseases
Chapter 6. Natural bioactive lead compounds effective against haematological malignancies
Chapter 7. Adjunct therapeutic potential of phytochemicals against cancer
Chapter 8. Antidiabetic lead compounds and targets for drug development
Chapter 9. Antiobesity functional leads and targets for drug development
Chapter 10. Phytochemicals as therapeutic interventions in neurodegenerative diseases
Chapter 11. Organosulfur phytochemicals against metabolic and neurodegenerative diseases: benefits and risks
Chapter 12. Lead compounds with the potentials for the treatment of chronic liver diseases
Chapter 13. Bioactive lead compounds effective against skin diseases
Chapter 14. Phytochemicals as emerging therapeutic agents for alopecia treatment
Chapter 15. Antiviral phytocompounds for drug development: a data mining studies
Chapter 16. Shikimic acid as intermediary model for the production of drugs effective against influenza virus
Chapter 17. Antimicrobial lead compounds from marine plants
Chapter 18. Antibacterial lead compounds and their targets for drug development
Chapter 19. Awareness and current therapeutic strategies of malaria
Chapter 20. Bioactive lead compounds and targets for the development of antimalarial drugs
Chapter 21. Bioactive lead compounds and molecular targets for the development of antiinflammatory drugs
Chapter 22. Functional lead compounds and targets for the development of drugs for the treatment of male infertility
Chapter 23. Prenylated flavonoids as a promising drug discovery candida
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