Polysaccharides in Advanced Drug Delivery 1st Edition by Akhilesh Vikram Singh, Bang Jing Li ISBN 1000050868 9781000050868

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ISBN 10: 1000050868
ISBN 13: 9781000050868
Author: Akhilesh Vikram Singh, Bang Jing Li

This book contains selective chapters from eminent experts working in the interdisciplinary arena of material science and its use in drug delivery. From their recent research experience, the readers can achieve a wide vision on the new and ongoing potentialities of polysaccharides and its application in the field of advanced drug delivery. This book contains selective polymers that were recently explored in the field of drug delivery such as starch, konjac, chitosan, alginate and other natural polymers originated from sea. It also has one chapter exclusively on nanotechnology that explains multifaceted application of natural polymer in the field of advanced drug delivery. Note: T& F does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.

Polysaccharides in Advanced Drug Delivery 1st Table of contents:

Chapter 1 Polysaccharide Carriers for Induction and Evaluation of Tissue Regeneration and Drug Delivery

1.1 Introduction

1.2 Role of Biomaterials for Induction of Tissue Regeneration

1.2.1 Polysaccharide as a Cell Scaffold to Induce Tissue Regeneration

1.2.2 Polysaccharide as a Transfection Carrier to Induce Tissue Regeneration

1.3 Role of Biomaterials in Evaluation of Tissue Regeneration

1.3.1 Polysaccharide as a Nano-sized Carrier for Cell Labeling

1.3.2 Polysaccharide as a Nano-sized Carrier for Targeting to the Regeneration Site

Conclusion

References

Chapter 2 Starch based Polymers for Drug Delivery Applications

2.1 Drug Delivery Systems

2.1.1 Conventional Free Drug Administration

2.1.2 Drug Delivery Systems Classification

2.1.3 Polymeric Materials in Drug Delivery

2.2 Starch as a Biomaterial

2.2.1 Native Starch

2.2.2 Modified Starch

2.2.3 Blends, Composites and Nanocomposites

2.3 Starch based Drug Delivery Systems

2.3.1 Gels and Hydrogels

2.3.2 Micelles

2.3.3 Capsules

2.3.4 Microparticles

2.3.5 Nanoparticles

2.3.6 Other Starch based Drug Delivery Systems

Conclusion

References

Chapter 3 Seaweed Polysaccharides in Advanced Drug Delivery Application to Carragennans

3.1 Introduction

3.2 Seaweed polysaccharides

3.2.1 Alginates

3.2.2 Carageenans

3.2.3 Agar Gum

3.2.4 Ulvans

3.2.5 Microbial Polysaccharides

3.2.6 Chitosan

3.3 Polymeric Drug Delivery Systems

3.4 Potential use of κ-carrageenan in Pharmaceutical Applications

3.4.1 Introduction

3.4.2 κ-carrageenan as a Gelling Agent

3.4.3 Carrageenans as a Blend Agent

3.4.4 Modified Kappa Carrageenan as an Excipients Agent

Conclusion

References

Chapter 4 Konjac Polysaccharide for Drug Delivery

4.1 Introduction

4.2 Konjac Glucomannan (KGM): Origin and Structure

4.3 Physicochemical Properties

4.3.1 Solubility

4.3.2 Molecular Weight

4.3.3 Gelation Properties

4.3.4 Derivates

4.4 KGM based Drug Delivery Systems

4.4.1 Blend with Polymers

4.4.2 Covalent Crosslinking

4.4.3 Polyelectrolyte Complex

4.3 Self-Assembly of KGM Derivates

4.3.1 Hydrophobically Modified KGM

4.3.2 Polyethylene Glycol Modified KGM

4.3.3 Others

Perspective

Reference

Chapter 5 Chitosan and Modified Chitosans for Drug Delivery Application

5.1 Introduction

5.2 Chemistry of Chitosan Relevant to its Chemical Modification and Drug Delivery

5.3 Chemically Modified Chitosan for Drug Delivery Systems

5.4 Importance of Mucoadhesive Properties of Chitosan in Drug Delivery Systems

5.5 Usage of Chitosan and Modified Chitosans in Drug Delivery Systems

Conclusion

References

Chapter 6 Alginate, Its Chemistry and Applications in Advanced Drug Delivery

6.1 Introduction

6.2 Sources of Alginate

6.3 Commercial Production of Alginate

6.4 Chemistry of Alginate

6.5 Physical Properties of Alginate

6.6 Chemical Properties of Alginate

6.7 Biocompatibilty

6.8 Gelling Methods

6.9 Applications of Alginate in the Advanced Drug Delivery

Conclusion

Acknowledgement

References

Chapter 7 Polysaccharides used for Microencapsulation Processes

7.1 Introduction

7.2 Microencapsulation of Drugs

7.3 Wall Materials for Microencapsulation

7.3.1 Gum Arabic

7.3.2 Alginate

7.3.3 Carrageenan

7.3.4 Starch and Modified Starches

7.3.5 Chitosan

7.3.6 Celluloses and Celluloses Derivatives

7.3.7 Others

Conclusion

References

Chapter 8 Polysaccharides used in Nanoparticle based Drug Delivery Formulations

8.1 Introduction

8.2 Polysaccharide-based Nanoparticles Fabricated by Crosslinking

8.2.1 Covalently Crosslinked Polysaccharide Nanoparticles

8.2.2 Ionically Crosslinked Polysaccharide Nanoparticles

8.3 Self-Assembling Polysaccharide-based Nanoparticles

8.3.1 Self-assembly of Hydrophobically Modified Polysaccharides

8.3.1.1 Linear Hydrophobic Molecules

8.3.1.2 Cyclic Hydrophobic Moieties

8.3.1.3 Polyacrylate Family Molecules

8.3.2 Polysaccharide-based Polymersomes

8.4 Polysaccharide Nanoparticles by Polyelectrolyte Complexation

8.4.1 Negative Polysaccharides

8.4.2 Negative Peptides

8.4.3 Others

8.5 Polysaccharide-based Hollow Nanospheres

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Tags: Akhilesh Vikram Singh, Bang Jing Li, Advanced Drug