Quantitative MRI of the Brain Principles of Physical Measurement Second Edition by Mara Cercignani,Nicholas G Dowell,Paul S Tofts ISBN 1138032859 978-1138032859

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Product details:

ISBN 10: 1138032859 

ISBN 13: 978-1138032859

Author: Mara Cercignani, Nicholas G. Dowell, Paul S. Tofts

Building on the success of the first edition of this book, the winner of the 2004 British Medical Association Radiology Medical Book Competition, Quantitative MRI of the Brain: Principles of Physical Measurement gives a unique view on how to use an MRI machine in a new way. Used as a scientific instrument it can make measurements of a myriad of physical and biological quantities in the human brain and body. For each small tissue voxel, non-invasive information monitors how tissue changes with disease and responds to treatment.

The book opens with a detailed exposition of the principles of good practice in quantification, including fundamental concepts, quality assurance, MR data collection and analysis and improved study statistical power through minimised instrumental variation. There follow chapters on 14 specific groups of quantities: proton density, T1, T2, T2*, diffusion, advanced diffusion, magnetisation transfer, CEST, 1H and multi-nuclear spectroscopy, DCE-MRI, quantitative fMRI, arterial spin-labelling and image analysis, and finally a chapter on the future of quantification. The physical principles behind each quantity are stated, followed by its biological significance. Practical techniques for measurement are given, along with pitfalls and examples of clinical applications.

This second edition of this indispensable ‘how to’ manual of quantitative MR shows the MRI physicist and research clinician how to implement these techniques on an MRI scanner to understand more about the biological processes in the patient and physiological changes in healthy controls. Although focussed on the brain, most techniques are applicable to characterising tissue in the whole body.

This book is essential reading for anyone who wants to use the gamut of modern quantitative MRI methods to measure the effects of disease, its progression, and its response to treatment.

Features:

• The first edition was awarded the book prize for Radiology by the British Medical Association in 2004
• Written by an authority in the field: Professor Tofts has an international reputation for quantification in MRI
• Gives specific ‘how to’ information for implementation of MRI measurement sequence techniques

Table of contents:

1. Concepts: Measurement in MRI

2. The measurement process: MR data collection and image analysis

3. Quality assurance: accuracy, precision, controls, and phantoms

4. Proton density of tissue water

5. T1: Longitudinal relaxation time

6. Quantitative T2 mapping in the brain

7. T2*: Susceptibility weighted imaging and quantitative susceptibility mapping

8. D: The diffusion of water (DTI)

9. Advanced models in diffusion MRI

10. MT: Magnetisation transfer

11. Quantitative chemical exchange saturation transfer

12. 1H spectroscopy

13. Multinuclear MR imaging and spectroscopy

14. T1-weighted dynamic contrast-enhanced MRI

15. qfMRI: Quantitative functional and metabolic MRI

16. ASL: Blood perfusion measurement using Arterial Spin Labelling

17. Image analysis

18. The future of qMRI

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Tags: Mara Cercignani, Nicholas G Dowell, Paul S Tofts, Quantitative MRI, of the Brain Principles, of Physical Measurement