Realizing the Promise of Precision Medicine 1st edition by Paul Cerrato,John Halamka 9780128116357 0128116358
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ISBN 10:0128116358
ISBN 13:9780128116357
Author:Paul Cerrato,John Halamka
Realizing the Promise of Precision Medicine: The Role of Patient Data, Mobile Technology, and Consumer Engagement explains the potential of personalized medicine and the value of those approaches in making that potential a reality. The book helps transform one-size-fits-all healthcare into a system that focuses on individual needs and the unique needs of each family member, discussing topics such as U.S. sponsored precision medicine initiative, genomics, the role of electronic health records and mobile medicine, patient engagement and empowerment, health information exchange and patient data protection.
In addition, the book discusses the barriers and limitations of precision medicine and how to overcome them. Readers will find valuable insights into how big data, patient engagement, mobile technology, and genomics help individualize medical care and offer a pathway to help detect many undiscovered causes of diseases.
- Provides drawings and flow charts to help readers visualize the breadth and depth of precision medicine
- Includes sidebars with more details on specific topics for a complementary, deeper understanding of the main text
- Uses case studies to turn abstract concepts into flesh and blood examples of how personalized medicine benefits patients
Realizing the Promise of Precision Medicine 1st Table of contents:
Chapter One. Population Medicine Versus Personalized Medicine
Cure Versus Management
The Limitations of Population-Based Medicine
Applying the Precision Medicine Model
How Does the Precision Medicine Initiative Fit Into the Equation?
Putting the Precision Medicine Model to Work Now
Understanding the Interlocking Contributors to Disease
The Biological Basis for Personalized Medicine
The Role of the Microbiome
Digital Tools That Enable Precision Medicine
Chapter Two. Precision Medicine Initiatives and Programs
The US Precision Medicine Initiative
Managing Data
Executing the US Precision Medicine Initiative
What Will the Precision Medicine Initiative Reveal?
The Age of Biomarkers is Upon Us
Patient Engagement: A Critical Component of Precision Medicine
The Value of Precision Medicine Initiative Data Reaches Beyond the US Precision Medicine Initiative Project
The Role of Electronic Health Record Data
Precision Medicine at Harvard
Precision Medicine at Columbia University
Johns Hopkins Approach to Individualized Care
Mayo Clinic Center for Individualized Medicine
Stanford University Emphasizes Patient Engagement
Chapter Three. The Role of Genomics
Genomic Basics
Putting Genomics to Use in Precision Medicine
Entering the Era of Precision Oncology
Is Cancer a Genetic Disease?
The Value of Pharmacogenomics
The Emerging Science of Nutritional Genomics
Chapter Four. Small Data, Big Data, and Data Analytics
Understanding the Language of Data Analytics
Algorithms and Machine Learning
Putting Data Analytics to the Test
The Role of Big Data in Hypothesis Testing
Reconciling Big Data and Randomized Controlled Trials
Chapter Five. How Mobile Technology and EHRs Can Personalize Healthcare
Accessing Patients’ “Other” Data
The Role of Mobile Technology in Diabetes Control
The Role of Mobile Technology in Other Diseases
Remote Patient Monitoring
Where Do EHRs Fit in?
Clinical Decision Support Systems
Star Trek–Like Decision-Making Tools
Chapter Six. i2b2, SHRINE, Clinical Query, and Other Research Tools
Taking Informatics for Integrating Biology and the Bedside Into New Territory
Shared Health Research Informatics Network Extends the Informatics for Integrating Biology and the Bedside Reach
The Impact of Shared Health Research Information Network on Scientific Research
Beth Israel Deaconess Medicine and Clinical Query 2
Moving Toward a National Network
Patient-Centered Outcomes Research Initiatives
Chapter Seven. Barriers and Limitations
Does Precision Medicine Cost Too Much?
Filling the Genomics Information Gap
Addressing the Workload Issue
Is There Adequate Scientific Evidence?
Additional Barriers to Surmount
Chapter Eight. Interoperability and Personalized Patient Care
Defining the Basics and Following a Roadmap
What Drives Interoperability?
Policy and Technical Components
Learning From Our Mistakes
Addressing Security Concerns
Understanding the Standards That Facilitate Interoperability
What Outcomes Can Be Expected?
Chapter Nine. Privacy and Security
Keeping Patient Data Safe at the Grassroots Level
Insecurity Is Expensive
Additional Health Insurance Portability and Accountability Act Violation Expenses
Calculating the Cost of Security
How Do the HIPAA Regulations Fit In?
Taking the Necessary Preventive Measures
Passwords, Policies, and Procedures
Technological Solutions
Applying Security Principles to Precision Medicine Initiative
A Case Scenario Requiring Security Protocols
Chapter Ten. Patient and Consumer Engagement
Engaging Responsible Patients
The Return on Investment
Patient Portals Are Not Enough
Shared Decision Making
Patient-Generated Data and Mobile Engagement
Final Thoughts on the Promise of Precision/Personalized Medicine
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