Recent Trends in Carbohydrate Chemistry 1st Edition by Amelia Pilar Rauter,Christensen,Laszlo 9780128209547 0128209542

Part One: Advances in chemical synthesis and biosynthesis of bacterial glycans

1: Prokaryotes: Sweet proteins do matter

Abstract

1 Introduction

2 Cell surface (S-) layer glycoproteins

3 Bacteria

4 Flagella/Archaella and fimbriae

5 Adhesins, bacteriocins, invasins, and glycocins

6 Spores

7 Concluding remarks

2: Glycan ligation reactions in the periplasmic space

Abstract

1 Introduction

2 WaaL O-antigen ligases

3 The ArnT family

4 Oligosaccharyl transferases

5 Conclusions

3: Synthesis of bioactive lipid A and analogs

Abstract

1 Lipid A—Structure, immunobiological function, and potential therapeutic significance

2 Synthesis of lipid A and analogs

3 Application of lipid A derivatives as vaccine adjuvants

4 Synthesis of lipid A modified by addition of amino sugars at the glycosidic phosphate group

5 Conclusion

4: Synthesis of lipopolysaccharide core fragments

Abstract

Acknowledgment

1 Introduction

2 Synthesis of LPS inner core fragments

3 Synthesis of outer core fragments

4 Conclusions

5: Synthesis of oligosaccharides related to potential bioterrorist pathogens

Abstract

1 Introduction

2 Bacillus anthracis

3 Burkholderia pseudomallei and Burkholderia mallei

4 Francisella tularensis

5 Yersinia pestis

6 Brucella spp.

7 Conclusion

6: Synthetic teichoic acid chemistry for vaccine applications

Abstract

1 Introduction

2 Synthetic teichoic acids

3 Conclusions

7: NMR characterization of bacterial glycans and glycoconjugate vaccines

Abstract

Acknowledgments

1 NMR characterization of carbohydrates

2 NMR analysis of surface carbohydrates of gram-negative bacteria

3 NMR analysis of surface carbohydrates of gram-positive bacteria

4 NMR analysis of glycoconjugate vaccines

5 Investigating antigen-antibody interactions using NMR spectroscopy

6 Conclusions

Part Two: Synthetic carbohydrate-based vaccines: present and future

8: Glycoconjugate vaccines, production and characterization

Abstract

Disclosures

1 Introduction

2 Conjugation chemistries

3 Physicochemical characterization and quality control of glycoconjugate vaccines

4 Conclusions

9: Antifungal glycoconjugate vaccines

Abstract

1 Introduction

2 Major human fungal pathogens

3 Carbohydrates in the molecular architecture of fungal CWs

4 Immunity against fungal pathogens

5 Glycoconjugates as antifungal vaccines

6 Glycoconjugates vaccines against Candida

7 Mannan glycoconjugates

8 β-Glucan glycoconjugates

9 Poly-N-acetyl-(1→6)-α-glucosamine glycoconjugates

10 Glycoconjugates vaccines against Aspergillus fumigatus

11 Glycoconjugates vaccines against Cryptococcus neoformans

12 Conclusion

10: Site-selective conjugation chemistry for synthetic glycoconjugate vaccine development

Abstract

Acknowledgments

1 Introduction

2 Homogeneous glycoprotein vaccine design

3 Conclusions and outlook

11: Glyconanoparticles as versatile platforms for vaccine development: A minireview

Abstract

1 Glyconanoparticles based on inorganic core

2 Glyconanoparticles based on polymeric core

3 Glyconanoparticles based on self-assembling core

4 Glyconanoparticles based on OMVs

5 Glyconanoparticles based on virus-like particles

6 Conclusions