Regulatory T cells in health and disease 1st Edition by Adrian Liston ISBN 9780128034156 0128034157

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Product details:

ISBN 10: 0128034157

ISBN 13: 9780128034156

Author: Adrian Liston

 Regulatory T Cells in Health and Disease focuses on the mechanism by which T cells become regulatory T cells, the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer.

Table of contents: 

Chapter One: Transcriptional and Epigenetic Control of Regulatory T Cell Development

Abstract

1 Introduction

2 Transcriptional Regulation in Treg Cells

3 Epigenetic Regulation in Treg Cells

4 Cross talk Between Foxp3-Dependent Gene Regulation and Treg Cell-Type Epigenetic Modifications

5 Treg Cell Development

6 Conclusion

Acknowledgment

Chapter Two: Microenvironment Matters: Unique Conditions Within Gut-Draining Lymph Nodes Favor Efficient De Novo Induction of Regulatory T Cells

Abstract

1 Introduction: Key Treg Characteristics

2 Peripheral De Novo Induction of Foxp3+ Tregs Within the Gastrointestinal Immune System

3 Outlook

Chapter Three: Understanding the Roles of the NF-κB Pathway in Regulatory T Cell Development, Differentiation and Function

Abstract

1 Introduction

2 NF-κB and Treg Development

3 NF-κB Involvement in Treg Function

4 Conclusion

Chapter Four: The Molecular Control of Regulatory T Cell Induction

Abstract

1 Introduction

2 Treg Differentiation in the Thymus

3 Peripheral Treg

4 Concluding Remarks

Acknowledgments

Chapter Five: The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells

Abstract

1 T Helper 17 Cells

2 Th17 Cells and Treg Cells: A Special Relationship

3 Concluding Remarks

Acknowledgments

Chapter Six: Mechanisms of Surveillance of Dendritic Cells by Regulatory T Lymphocytes

Abstract

1 Of Mice and Men: An Historical Perspective on Tregs

2 Immunosuppressive Mechanisms of Tregs

3 Tregs Impair DC Function

4 Concluding Remarks

Chapter Seven: Development and Function of Effector Regulatory T Cells

Abstract

1 Introduction

2 Features of Effector T Regulatory Cells

3 Role of TCR Signaling in Effector T Regulatory Cell Differentiation

4 Cytokine Requirements of Effector T Regulatory Cells

5 Distinct Migratory Properties of Effector T Regulatory Cells

6 Functional Specialization of Effector T Regulatory Cells

7 Effector T Regulatory Cells in Nonlymphoid Organs

8 A Unified Model of Effector T Regulatory Cell Differentiation

9 Future Perspectives

Acknowledgments

Chapter Eight: Treg Cell Differentiation: From Thymus to Peripheral Tissue

Abstract

1 Introduction

2 Thymic Treg Cells

3 Further Differentiation of Treg Cells in the Periphery

4 Future Perspectives

Acknowledgments

Chapter Nine: Regulatory T cells in Arthritis

Abstract

1 Introduction

2 Treg Cells in the Inflammation That Occurs in RA

3 Treg Cells in the Bone Destruction in RA

4 The Plasticity of Foxp3+ T Cell in Arthritis

5 Treg Cell-Targeted Therapies Against RA

6 Conclusions

Acknowledgment

Chapter Ten: The Immune Fulcrum: Regulatory T Cells Tip the Balance Between Pro- and Anti-inflammatory Outcomes upon Infection

Abstract

1 Introduction

2 Acute Infections in Delicate Tissues

3 Acute Systemic Viral Infections

4 Gastrointestinal Infections

5 Chronic Infections

6 Conclusions and Future Directions

Chapter Eleven: Regulatory T Cells in Autoimmune Diabetes: Mechanisms of Action and Translational Potential

Abstract

1 Introduction

2 Sites of Treg Action in T1D

3 Mechanisms of Treg Suppression in T1D

4 Therapeutic Manipulation of Treg in T1D

5 Concluding Remarks

Acknowledgments

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Tags: Adrian Liston, Regulatory, T cells, Health Disease