Role of Exosomes in Biological Communication Systems 1st Edition by Faisal A Alzahrani, Islam M Saadeldin ISBN 9811566011 978-9811566011

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Product details:

ISBN 10: 9811566011 

ISBN 13: 978-9811566011

Author: Faisal A. Alzahrani, Islam M. Saadeldin

 This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.

Table of contents: 

1. Isolation and Characterization of Extracellular Vesicles: Classical and Modern Approaches

2. Characterization and Fine Structure of Exosomes

3. Extracellular Vesicles Mediate the Embryonic-Maternal Paracrine Communication

4. The Interplay Between Oviduct-Derived Exosomes and Cumulus-Oocyte Complexes

5. The Interplay Between Exosomes and Spermatozoa

6. Mesenchymal Stem Cell–Derived Exosomes and Regenerative Medicine

7. Therapeutic Potential of Mesenchymal Stem/Stromal Cell–Derived Exosomes

8. Exosomes in Neurodegenerative Disorders

9. Differential Expression of Exosomal MicroRNAs in Neurodegenerative Diseases

10. Urinary Exosomes as a Possible Source of Kidney Disease Biomarkers

11. Extracellular Vesicles as Potential Therapeutic Targets and Biomarkers for Liver Disease

12. Implications of Extracellular Vesicles in Blood Protozoan Parasitic Diseases

13. Cancer Cells–Derived Exosomes and Metastasis

14. Extracellular Vesicles and Integrins: Partners in Cancer Progression

15. Exosomes: The Crucial Element in Prostate Cancer

16. Exosomal microRNAs: Potential Biomarkers for Cancer Diagnosis, Treatment Response and Prognosis

17. Exosomes in Drug Delivery

18. Exosomes and Supported Lipid Layers as Advanced Naturally Derived Drug Delivery Systems

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Tags: Faisal A Alzahrani, Islam M Saadeldin, Exosomes, Biological Communication Systems