Sarcopenia Molecular Cellular and Nutritional Aspects 1st Edition by Dominique Meynial Denis ISBN 1032084286 9781032084286

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ISBN 10:    1032084286
ISBN 13: 978-1032084282
Author:      Dominique Meynial-Denis

Sarcopenia: Molecular, Cellular, and Nutritional Aspects describes the progressive loss of skeletal muscle mass and strength, defined by Rosenberg in 1997 as a hallmark of aging and referred to as “sarcopenia”. As life expectancy continues to increase worldwide, sarcopenia has become a major public health issue. The condition worsens in the presence of chronic diseases that accelerate its progression. Sarcopenia is not considered to be “a process of normative aging” but according to the International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM), as a disease. As sarcopenia is an unavoidable process, prevention and management are the only options to promote healthy aging, actions that should perhaps should perhaps be taken during youth.

Included in this book:

· Features essential information on sarcopenia, its current definition, and molecular and cellular aspects of this disease

· Discusses the development of physical frailty, a complication of sarcopenia, and predicts its occurrence in the older population

· Presents alterations in muscle protein turnover and mitochondrial dysfunction in the aging process

· Provides data on the negative involvement of sarcopenia in certain chronic diseases that can lead to cachexia, a metabolic wasting syndrome

· Describes presbyphagia or age-related changes in the swallowing mechanism in older people

· Details possible strategies to combat muscle wasting in healthy older adults and their limitations

This book features information collected from pioneers or experts on human aging from around the globe, including Europe, Brazil, Canada, Japan and the United States. It is a valuable source of information for nutritional scientists, medical doctors, sports scientists, food scientists, dietitians, students in these fields, and for anyone interested in nutrition. We hope this book provides a better understanding of sarcopenia which inevitably occurs with aging without weight loss. The book also provides information outlining strategies to prevent or limit muscle wasting due to normal aging in order to promote successful aging.

Sarcopenia-Molecular, Cellular, and Nutritional Aspects 1st Table of contents:

SECTION I Basics of Sarcopenia: Definition and Challenges of Sarcopenia Research

Chapter 1 Definitions of Sarcopenia

SECTION II New Data on Sarcopenia

Chapter 2 Models of Accelerated Sarcopenia

Chapter 3 Sarcopenia in Physical Frailty

SECTION III Molecular and Cellular Aspects of Sarcopenia

Chapter 4 The Role of Imaging Techniques in the Diagnosis of Sarcopenia

Chapter 5 Nutrient Sensing and mTORC1 Regulation in Sarcopenia

Chapter 6 Different Adaptation of Ubiquitin-Proteasome and Lysosome-Autophagy Signaling in Sarcopenic Muscle

Chapter 7 Myokines in Aging Muscle

Chapter 8 The Contribution of Satellite Cells to Skeletal Muscle Aging

Chapter 9 Muscle Stem Cell Microenvironment in Sarcopenia

Chapter 10 Sarcopenia and Oxidative Stress: From the Bench to Therapeutic Strategies

SECTION IV Alterations in Muscle Protein Turnover in the Aging Process

Chapter 11 Muscle Protein Turnover and Sarcopenia in the Elderly: The Effects of Nutrition

Chapter 12 The Relationship between Muscle Mitochondrial Turnover and Sarcopenia

Chapter 13 Skeletal Muscle Fat Infiltration with Aging: An Important Factor of Sarcopenia

SECTION V Recent Advances Limiting Sarcopenia and Supporting Healthy Aging

Chapter 14 Nutritional Modulation of Mitochondria-Associated Death Signaling in Sarcopenia

Chapter 15 Beneficial Effects and Limitations of Strategies (Nutritional or Other) to Limit Muscle Wasting due to Normal Aging

SECTION VI Applications

Part 1: Muscle Impairments or Diseases due to the Frailty Induced by Sarcopenia

Chapter 16 Declines in Whole Muscle Function with Aging: The Role of Age-Related Alterations in Contractile Properties of Single Skeletal Muscle Fibers

Chapter 17 Sarcopenic Dysphagia, Presbyphagia, and Rehabilitation Nutrition

Part 2: Complications due to Sarcopenia in Acute or Chronic Diseases

Chapter 18 Wasting and Cachexia in Chronic Kidney Disease

Chapter 19 Sarcopenia and Parkinson’s Disease: Molecular Mechanisms and Clinical Management

Chapter 20 Sarcopenic Obesity in the Elderly

Chapter 21 Sum Up and Future Research

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