Studies in Natural Products Chemistry 49 1st Edition by Atta Ur Rahman 0128179048 9780128179048

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ISBN-10 :  0128179048 

ISBN-13 : 9780128179048

Author:  Atta-Ur-Rahman 

Studies in Natural Products Chemistry, Volume 64, covers the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques that have made it possible to rapidly isolate and determine the structures and biological activity of natural products. The book highlights these new and exciting opportunities in the field of new drug development to the pharmaceutical industry. As natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects, this book is an ideal resource on the material presented.

Studies in Natural Products Chemistry 49 1st Table of contents:

Chapter 1: The C-19 methyl substituted sarpagine-macroline-ajmaline alkaloids: Diversity, occurrence, bioactivity, and synthesis
Abstract
Introduction
Occurrence
Bioactivity
Biosynthesis and synthesis (partial, formal, and total synthesis) of the alkaloids from this subgroup
Conclusion
Acknowledgments
Chapter 2: Recent progress in the synthesis of antimalarial indoloquinoline natural products and analogues
Abstract
Introduction
Quinoline natural products
Synthesis of isocryptolepine, cryptolepine, and neocryptlepine
Preparation of analogues for medicinal chemistry
Concluding remarks
Acknowledgments
Chapter 3: Anticancer activity of natural coumarins for biological targets
Abstract
Introduction
What are coumarins briefly?
What is cancer briefly?
Coumarins on anticancer effects
Some coumarins and plants with anticancer effects
Concluding remarks
Chapter 4: Silymarin compounds: Chemistry, innovative extraction techniques and synthesis
Abstract
Introduction
Silymarin compounds
Identification and analytical issues
Innovative extraction technologies
Synthesis targeting biological activity
Concluding remarks
Acknowledgments
Chapter 5: The olive-tree leaves as a source of high-added value molecules: Oleuropein
Abstract
Introduction
The olive tree
Phenolic compounds
Oleuropein
Factors that influence oleuropein and phenolic levels
Extraction, purification and analytical methods
Valorisation of oleuropein
Conclusions
Acknowledgments
Chapter 6: Progress in studies on meroterpenoids
Abstract
Introduction
Prenylphenols and prenylflavonoids
Terpenic alkaloids
Isoprenoid lipids
Isoprenyl glycosides
Conclusion
Acknowledgments
Chapter 7: Effects of dietary n-3 polyunsaturated fatty acids on cardiovascular disease
Abstract
Introduction
Underlying CVD disorders and mechanisms
Sources of DHA, EPA, and ALA
Biosynthesis of DHA and EPA from ALA and production of eicosanoids
Epidemiological studies on the effect of fish and n-3 PUFA consumption on CVD risk
Mechanisms and protective effects of n-3 PUFA in vascular endothelial dysfunction
Conclusion
Chapter 8: Potential of natural bioactive C-glycosyl flavones for antidiabetic properties
Abstract
Introduction to C-glycosyl flavones
Production of C-glycosyl flavones in plants
Structure and activity of C-glycosyl flavones
Biochemical pathway of inflammation and diabetes
Rationale of C-glycosyl flavones as antidiabetic drugs
Future prospective of natural flavone C-glycosides
Chapter 9: Natural products encompassing antituberculosis activities
Abstract
Introduction
Alkaloids
Flavonoids
Lignans
Coumarins
Terpenes
Conclusion
Acknowledgment
Chapter 10: Physiological effects of carotenoids on hyperglycemia and associated events
Abstract
Introduction
Life-style associated hyperglycemia
Carotenoids: Structure, biosynthesis, function and metabolism
Hyperglycemia induced pathological conditions and protective role of carotenoids
Conclusion and future perspectives
Chapter 11: Pharmacophore modeling and virtual screening for the discovery of biologically active natural products
Abstract
Introduction
A historical perspective in discovery of biologically active NPs
Impact of NPs chemistry in drug discovery
Pharmacophore modeling
Strategy of virtual screening for the discovery of bioactive NPs
Concluding remarks
Chapter 12: Formation of three-dimensional polymer structures through radical and ionic reactions of peroxychitosan
Abstract
Introduction
Synthesis, properties, and applications of chitosan
Synthesis of peroxychitosans by the method of polymer-analogous reaction through the peroxidation of chitosan with tert-butylperoxymethyl maleate: The mechanism of thermal decomposition of peroxychitosans
Synthesis of peroxidated chitosan via graft copolymerization with a peroxide monomer
Synthesis of pH-sensitive self-assembled peroxide-containing submicron particles based on chitosan and oligoperoxide
Conclusions
Chapter 13: Bioactive natural products as potent inhibitors of xanthine oxidase
Abstract
Introduction
XO- A promising therapeutic target for the treatment of various diseases
XO inhibitors in the treatment of liver diseases
XO inhibitors in the treatment of heart diseases
XOI for hypertension and renal diseases
XOI in the treatment of other diseases
Medicinal plants as potent XO inhibitors
Medicinally important plants with reported XO inhibitory activities
Phytochemicals with XO inhibitory potential
XO inhibitors from natural sources other than medicinal plants
Inhibitory mechanisms of phytochemicals on XO
Conclusion
Chapter 14: Organocatalyzed α-aminooxylation/amination of aldehydes and their sequential reactions: A versatile tool for the synthesis of bioactive molecules
Abstract
Introduction
Mechanism of catalysis
Proline catalyst and its mechanism of action
Proline-catalyzed α-aminooxylation
Sequential reactions
Proline-catalyzed α-aminooxylation and its sequential reactions
Sequential α-aminooxylation and cis-Wittig olefination
Sequential α-aminoxylation-allylation reactions
Sequential α-aminoxylation-Henry reaction
Proline catalyzed sequential α-aminooxylation/reductive cyclization of o-nitrohydrocinnamaldehyde
Proline-catalyzed α-amination
Proline-catalyzed sequential α-amination-Horner-Wadsworth-Emmons olefination of aldehydes
Proline-catalyzed sequential α-amination-allylation of aldehydes
Proline catalyzed sequential α-amination/reductive cyclization of o-nitrohydrocinnamaldehyde
Proline catalyzed sequential α-amination/benzoyloxyallylation of aldehydes
Conclusion
Aknowledgments
Chapter 15: Bioactive compounds of Streptomyces: Biosynthesis to applications
Abstract
Introduction
Modular type-I polyketide synthase (Type-I PKS)
Type -II PKS
Type III PKS
Examples of polyketides derived secondary metabolites
Genome mining: Prediction of lipopeptides and polyketides

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