Systemic Lupus Erythematosus Basic Applied and Clinical Aspects 2nd Edition by George 0128145528 9780128145524

Systemic Lupus Erythematosus Basic Applied and Clinical Aspects 2nd Edition George Tsokos – Ebook Instant Download/Delivery ISBN(s): 0128145528, 9780128145524

Product details:

• ISBN 10: 0128145528
• ISBN 13: 9780128145524
• Author: George Tsokos

This completely updated and expanded 2nd edition of Systemic Lupus Erythematosus, A Manual includes topics not covered previously with contributors who are at the forefront of each specific topic and with a global appeal. Each chapter is short and is presented critically with selected references, which should be valuable to a wider audience. This book combines basic with clinical science to help internists and specialists in the diagnosis and management of patients with SLE. It is a quick referral for people in the pharmaceutical industry in their efforts to bring much-needed drugs. It provides all the needed information to basic researchers old and new alike, who wish to enter the field of lupus and systemic autoimmunity in general.

Table of contents:

Part I – Epidemiology and diagnosis

Chapter 1 – History of systemic lupus erythematosus with an emphasis on certain recent major issues

History of clinical observations

The age of dermatology

Transition of lupus erythematosus to systemic lupus erythematosus

History of laboratory investigations

Development of clinical tests

History of genetics of SLE

History of therapy in SLE with an emphasis on the use of steroids

History of classification criteria for SLE

References

Chapter 2 – The patient

Improve the interactions with your patients

Do not make your patient wait

Smile as you enter the patient’s room

Make a visible show of hand washing

Shake hands

Acknowledge and greet others in the room

Ask open-ended questions

Provide a mechanism for your patient to set the agenda

Speak in nonmedical terms

Be honest

Learn to be empathetic

Always examine your patient

End the visit with, “Do you have any other concerns or questions?”

Consulting in the hospital

Improving adherence

Disability

Patient education

The lupus secrets

References

Chapter 3 – A plea of a young patient to the lupus experts

Reference

Chapter 4 – Epidemiology

Introduction

Incidence and prevalence

Distribution according to gender

Distribution according to age

Distribution according to ethnic/racial group

Distribution around the world

Factors that affect the course of SLE

Impact of race/ethnicity

Impact of gender

Mortality and survival in SLE

References

Chapter 5 – Measuring disease activity

References

Chapter 6 – Disease development and outcome

Historical perspective

Clinical manifestations

Assessment of disease activity

Disease damage

Patient reported outcomes

Mortality

Causes of death

Treatment guidelines and quality indicators

Conclusions

References

Chapter 7 – Socioeconomic aspects of SLE

Introduction

Sociodemographic determinants of health in SLE

Gender as a construct in risk and morbidity

Race/ethnicity as a multidimensional determinant of outcomes

Age and aging

Income, poverty, and educational attainment

Healthcare access and utilization

Health literacy

Health insurance

The economic burden of SLE

Work and disability

Individual and societal costs

Conclusion

References

Chapter 8 – Biomarkers in systemic lupus erythematosus

Introduction

Biomarker definition and validation

Biomarkers for diagnosis of SLE

Cell-bound complement activation products

Interferon-α and interferon-α-inducible genes

T-cell gene expression assays

DNA methylation

Plasma thermograms

Biomarkers for measuring SLE disease activity

Cell-bound complement activation proteins

Interferon-α and interferon-α-inducible genes

B-lymphocyte stimulating factor/B-cell activating factor

MicroRNAs

Tumor necrosis factor α

CD27high plasma cells

CD44+ T cells

Biomarkers to detect specific organ involvement

Lupus nephritis biomarkers

Antibodies to complement C1q

Monocyte chemoattractant protein-1

Neutrophil gelatinase-associated lipocalin

Urinary TWEAK

MicroRNAs

Hepcidin

Urinary biomarker panels

Central nervous system biomarkers

Anti-NMDA receptor antibody

Antiribosomal P antibody

Antiphospholipid antibodies

Platelet-bound C4d

Other

Cardiovascular system biomarkers

Respiratory system biomarkers

Lupus arthritis biomarkers

Genetic susceptibility and theranostics

Conclusions

References

Part II – Pathogenesis

Chapter 9 – Overview of the pathogenesis of systemic lupus erythematosus

Genetics

Epigenetics

Gender

Environment

Immune dysregulation

Tissue damage

Conclusions

References

Chapter 10 – System lupus erythematosus and the environment

Introduction

Infectious agents, dysbiosis the microbiome, and SLE

Cigarette smoking, alcohol and SLE

Cosmetics, chemicals, and risk of SLE

Ultraviolet radiation, vitamin D, and SLE

Drugs, vaccines, and SLE

Geography, socioeconomics, and SLE

Conclusion

References

Chapter 11 – Genes and genetics in human SLE

Introduction

Transcription factors

Clearance of apoptotic cells and immune complexes

Autophagy

Type I IFN pathway

NFkB pathway

Neutrophils and NETosis

T cell signaling

B cell signaling

Genes and phenotypes

SLE risk genes as therapeutic targets

Drug repositioning and predicting clinical outcomes

Conclusions

References

Chapter 12 – Monogenic lupus

Introduction

Complement deficiency

Deficiencies in DNA damage repair and clearance

DNase1L3

DNase II

DNase III/TREX1

Abnormalities of DNA sensing

Stimulator of interferon genes (STING)

IFIH1

Other interferonopathies

Apoptosis

Fas/FasL

Cell signaling

PKCδ

Ras

STAT1

Implications for SLE as a whole

Conclusion

References

Chapter 13 – Hormones

Sex hormones

Estrogen-estrogen receptor signaling

Estrogen and the immune response

Innate immune response

Adaptive immune response

B cells

T cells

Estrogen and SLE

Other hormones

Hormone therapy

Conclusions

References

Chapter 14 – Clinical aspects of the complement system in systemic lupus erythematosus

Introduction

General comments

Historical notes

Complement testing and its interpretation

Serum levels and hemolytic activities for C4 and C3

Interpretation of C4 and C3 complement tests in SLE

Consumption versus biosynthesis

Chronically low C4 and C3: How to interpret?

When C4 and C3 are discrepant

Cryoglobulins

Cold activation

Copy-number variation (CNV)

Alternative pathway activation

New developments

Assessing a therapeutic response

Interpretation

Renal biopsy

New connections for lupus and complement

Local synthesis

Activation by local proteases

Intracellular complement activation

Exogenous coating with opsonic fragments leads to endogenous consequences

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