The Biology and Therapeutic Application of Mesenchymal Cells Set 1st Edition by Kerry Atkinson 9781118907511 1118907515

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ISBN 10:1118907515
ISBN 13:9781118907511
Author:Kerry Atkinson

The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues.

• Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications
• Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models
• Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues
• Written and edited by leaders in the field

The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine.

The Biology and Therapeutic Application of Mesenchymal Cells Set 1st Table of contents:

SECTION I : An overview of mesenchymal stem cells and mesenchymal stromal cells

The mesenchymal stem cell, the mesenchymal stromal cell, and the mesenchymal stromal cell exosome 

The nomenclature of mesenchymal stem cells and mesenchymal stromal cells 

SECTION II : The isolation and ex vivo expansion of mesenchymal stromal cells

The isolation and expansion of mesenchymal stromal cells from bone marrow 

The biology and clinical applications of mesenchymal stromal cells derived from human gestational tissues 

Human placenta-derived mesenchymal stem/stromal cells: fetal and maternal origins and critical parameters for ex vivo expansion

SECTION III : The cellular and molecular biology of mesenchymal stromal cells

Epigenetic regulation of mesenchymal stem/stromal cell growth and multipotentiality

Biological changes in human mesenchymal stromal cells during monolayer culture 

The effect of three-dimensional aggregates on the biology of mesenchymal stromal cells 

Cell–cell signaling pathways that regulate mesenchymal stromal cell differentiation 

Regulation of mitochondrial transport in mesenchymal stromal cells 

The regulation of adipogenesis from adipose-derived stem/stromal cells 

Modulation of osteogenic differentiation in mesenchymal stromal cells 

The role of glycogen synthase kinase-3 inhibitors on bone remodeling 

Early molecular events during in vitro chondrogenesis

The role of the extracellular matrix in the differentiation of mesenchymal stromal cells 

Effects of hypoxic culture on bone marrow multipotent mesenchymal stromal cells: from bench to bedside

The role of cyclic tensile strain on osteogenesis and angiogenesis in human mesenchymal stem/stromal cells 

The evolving concept of mesenchymal stromal cells in regenerative medicine: from cell differentiation to secretome 

The secretome of mesenchymal stem/stromal cells undergoing chondrogenic differentiation and those undergoing osteogenic or adipogenic differentiati

Mesenchymal stromal cell extracellular vesicles/exosomes

on 

Role of tunneling nanotube crosstalk with distressed cardiomyocytes in controlling the heart repair potential of mesenchymal stromal cells 

The preferential homing of mesenchymal stromal cells to sites of inflammation 

The role of chemokines in mesenchymal stromal cell homing to sites of inflammation, including infarcted myocardium

Live cell imaging and single cell tracking of mesenchymal stromal cells in vitro 

The role of mesenchymal stem/stromal cells in angiogenesis 

The relationship between mesenchymal stromal cells and endothelial cells 

The radioresistance of mesenchymal stromal cells and their potential role in the management of radiation injury

Mesenchymal stem/stromal cell therapy: mechanism of action and host response 

The differences between mesenchymal stromal cells and fibroblasts 

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