The Chemical Biology of Long Noncoding RNAs Stefan Jurga 303044743X 9783030447434

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Product details:

• ISBN 10: 303044743X
• ISBN 13: 9783030447434
• Author:  Stefan Jurga

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.

Table of contents:

Long Non-coding RNAs Diversity in Form and Function: From Microbes to Humans

Evolving Roles of Long Noncoding RNAs

Biogenesis and Function of the Noncoding Isoform-Type LncRNAs

Long Non-coding RNAs in a Single-Cell Type: Function and Subcellular Localization

Long Noncoding RNAs as Scaffolds for Multiprotein Signaling Complexes

Landscape of Long Noncoding RNA Genes, Pseudogenes, and Protein Genes in Segmental Duplications in the Critical Human Chromosomal Region 22q11.2

Long Non-coding RNAs and Cancer Cells’ Drug Resistance: An Unexpected Connection

Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma

Single-Cell Analysis May Shed New Lights on the Role of LncRNAs in Chemoresistance in Gastrointestinal Cancers

LncRNAs in the Development, Progression, and Therapy Resistance of Hormone-Dependent Cancer

Tumorigenesis-Related Long Noncoding RNAs and Their Targeting as Therapeutic Approach in Cancer

Long Noncoding RNAs in Non-Small Cell Lung Cancer: State of the Art

Long Noncoding RNAs in Cardiovascular Diseases

Long Noncoding RNAs in Cardiovascular Development and Diseases

Long Noncoding RNAs as Players in Breast Tumorigenesis

Drosophila Models to Study Long Noncoding RNAs Related to Neurological Disorders

Regulatory Roles of Long Non-coding RNAs in Skeletal Muscle Differentiation, Regeneration, and Disorders

Long Noncoding RNAs in Substance Use Disorders

The Multifaceted Roles of LncRNAs in Diabetic Complications: A Promising Yet Perplexing Paradigm

Long Noncoding RNAs in Diabetes and β-Cell Regulation

Correction to: Long Noncoding RNAs as Players in Breast Tumorigenesis

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