The Immune Response to Implanted Materials and Devices The Impact of the Immune System on the Success of an Implant 1st Edition Bruna Corradetti 3319454331 9783319454337

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Product details:

• ISBN 10: 3319454331
• ISBN 13: 9783319454337
• Author: Bruna Corradetti

This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration).

Table of contents:

Chapter 1: Host Response to Implanted Materials and Devices: An Overview

Chapter 2: Implications of the Acute and Chronic Inflammatory Response and the Foreign Body Rea

Chapter 3: Macrophages: The Bad, the Ugly, and the Good in the Inflammatory Response to Bioma

Chapter 4: Understanding Nanoparticle Immunotoxicity to Develop Safe Medical Devices

Chapter 5: Host Response to Synthetic Versus Natural Biomaterials

Chapter 6: Convergence of Osteoimmunology and Immunomodulation for the Development and Assessme

Chapter 7: Modulation of Innate Immune Cells to Create Transplant Tolerance

Chapter 8: Inflammatory Cytokine Response to Titanium Surface Chemistry and Topography

Chapter 9: The Biomechanical Environment and Impact on Tissue Fibrosis

Chapter 10: Advancing Islet Transplantation: From Donor to Engraftment

Chapter 11: Targeted Modulation of Macrophage Functionality by Nanotheranostics in Inflammatory Li

Chapter 12: T-Cell Mediated Immunomodulation and Transplant Optimization

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