Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography 1st Edition by Steven Wong ISBN 0824772466 9780824772468

1. Introduction

2. Fundamentals and Current Clinical Instrumentation

3. Principles of Therapeutic Drug Monitoring

• I. Introduction
• II. Pharmacodynamics: Site and Mechanism of Drug Action
• III. Pharmacokinetics
• IV. Guidelines for Routine Therapeutic Drug Monitoring
• V. Conclusion
• References

4. Liquid Chromatography and Other Methodologies for Therapeutic Drug Monitoring and Toxicology

• I. Introduction
• II. Liquid Chromatography
• III. Gas Chromatography
• IV. Radioimmunoassay (RIA)
• V. Enzyme Multiplied Immunoassay Techniques (EMIT)
• VI. Fluorescence Polarization Immunoassay (FPIA) Using TDX
• VII. Substrate-Labeled Fluorescence Immunoassay (SLFIA)
• VIII. Nephelometric Inhibition Immunoassay (NIIA)
• IX. Latex Agglutination Inhibition Test for Gentamicin and Tobramycin
• X. Enzyme-Linked Immunosorbent Assay: ELISA Enzymune-Test™
• XI. Fluorescent Immunoassay: Amerifluor™
• XII. Prosthetic Group Label Immunoassay (PGLIA)
• XIII. Automated Turbidimetric Inhibition Assay for Theophylline
• XIV. Conclusion
• References

5. Sampling Technique

• I. Introduction
• II. Devices
• III. Components of Materials Used in Specimen Collection Devices
• IV. Influence of Specimen Collection in Toxicology
• V. Conclusion
• References

6. Computer Control of Liquid Chromatographic Analyses

• I. Introduction
• II. The Anatomy of a Computer-Controlled Liquid Chromatographic System
• III. Computer-Controlled Collection of Liquid Chromatographic Data
• IV. Data Handling
• V. The Selection of an Automatic Liquid Chromatographic System
• References

7. Combined Liquid Chromatography-Mass Spectrometry of Drugs

• I. Introduction
• II. Off-Line LC-MS
• III. On-Line LC-MS
• IV. LC-MS, MS-MS, and LC-MS-MS
• V. Discussion
• VI. Conclusion
• References

8. Drug Determination in Biological Fluids by Liquid Chromatography-Fluorescence

• I. Introduction
• II. Basic Concepts
• III. Instrumentation
• IV. Applications of LC-Native Fluorescence
• V. Precolumn Derivatization
• VI. Postcolumn Derivatization
• VII. Phosphorescence
• References

9. Liquid Chromatography-Electrochemistry: Potential Utility for Therapeutic Drug Monitoring

• I. Introduction to Liquid Chromatography-Electrochemistry (LC-EC)
• II. Electroactive Drugs
• III. Review of Applications
• IV. Future Directions
• V. Conclusion
• References

II. Major Classes of Drugs

10. Antiasthmatics

• I. Introduction
• II. Rationale for Xanthine Monitoring
• III. Liquid Chromatography
• IV. Interferences
• V. Reliability of Analytical Procedures
• VI. Conclusion
• References

11. Antibiotics

• I. Introduction
• II. General Considerations
• III. Review of Liquid Chromatographic Methods
• IV. Conclusion
• References

12. Antidepressants

• I. Introduction
• II. Historical Perspectives
• III. Hypotheses for Depression
• IV. Clinical Pharmacology
• V. Rationale for Antidepressant Monitoring and the Role of the Laboratory
• VI. Sampling Considerations
• VII. Antidepressant Assays
• References

13. Anticonvulsants

• I. Introduction
• II. The Rationale for Therapeutic Drug Monitoring
• III. Clinical Pharmacology
• IV. Measurement of Anticonvulsant Drugs by HPLC
• References

14. Antihypertensives

• I. Introduction
• II. Drugs with Central Modes of Action
• III. Drugs Acting at the α-Adrenoceptor Sites
• IV. β-Adrenoreceptor Antagonists
• V. Diuretics
• VI. Inhibitors of the Renin-Angiotensin System
• VII. Vasodilators
• VIII. Drugs with Miscellaneous Modes and Sites of Action
• IX. Conclusion
• References

15. Antiarrhythmics

• I. Introduction
• II. Preparation of Samples
• III. Chromatography
• IV. Detection and Quantitation
• V. Analysis of Metabolites
• VI. Very-High-Speed Liquid Chromatography
• References

III. Laboratory Management and Miscellaneous Topics

16. Medicolegal Guidelines for the Clinical Toxicology Laboratory

• I. Introduction
• II. The Medicolegal Environment
• III. Minimizing Liability
• IV. The Medicolegal Sample
• V. Medicolegal Testimony
• VI. Conclusion
• Bibliography

17. Drugs and Laboratory Management: Clinical and Technical Considerations

• I. Introduction
• II. LC Drug Analysis
• III. Laboratory Management
• References

18. Conclusion: Current Status and Future Developments