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Translational Pancreatic Cancer Research From Understanding of Mechanisms to Novel Clinical Trials 1st edition by Christoph Michalski, Jonas Rosendahl, Patrick Michl, Jörg Kleeff 3030494759 9783030494759

Name: Translational Pancreatic Cancer Research From Understanding of Mechanisms to Novel Clinical Trials 1st edition by Christoph Michalski, Jonas Rosendahl, Patrick Michl, Jörg Kleeff 3030494759 9783030494759
SKU: EB-22504476
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Translational Pancreatic Cancer Research From Understanding of Mechanisms to Novel Clinical Trials Christoph W. Michalski Digital Instant Download

Author(s): Christoph W. Michalski, Jonas Rosendahl, Patrick Michl, Jörg Kleeff

ISBN(s): 9783030494759, 9783030494766, 3030494756, 3030494764

Edition: 1st ed.

File Details: PDF, 12.12 MB

Year: 2020

Language: English

SKU: EB-22504476 Category: Medicine Tags: Christoph W. Michalski, Jonas Rosendahl, Jörg Kleeff, Patrick Michl

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Translational Pancreatic Cancer Research From Understanding of Mechanisms to Novel Clinical Trials 1st edition by Christoph W. Michalski, Jonas Rosendahl, Patrick Michl, Jörg Kleeff – Ebook PDF Instant Download/Delivery: 3030494759, 9783030494759
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Product details:

ISBN 10: 3030494759

ISBN 13: 9783030494759

Author: Christoph W. Michalski, Jonas Rosendahl, Patrick Michl, Jörg Kleeff

This book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approaches to biomarker development are important as both prognostic and predictive tools. The final part consists of personalized treatment approaches that include preclinical models of pancreatic cancer and stromal, epigenetic and metabolism targeting as promising approaches to be translated into early phase clinical trials. Chapters within this part also deal with approaches that are close to being implemented in clinical practice or are already being tested in (early) clinical trials, such asthose that targeting the immune systems and strategies to overcome immunotherapy resistance; phase 1 clinical trials and translational approaches in surgical treatment.

Translational Pancreatic Cancer Research From Understanding of Mechanisms to Novel Clinical Trials 1st Table of contents:

Subtypes of Pancreatic Adenocarcinoma
PDAC Precursors and Early Diagnosis
Surveillance and Intervention in IPMN
Novel Biomarkers of Invasive IPMN
Challenges and Opportunities for Early Pancreatic Cancer Detection: Role for Protein Biomarkers
Metabolic Biomarkers of Pancreatic Cancer
Blood-Based Circulating RNAs as Preventive, Diagnostic, Prognostic and Druggable Biomarkers for Pancreatic Ductal Adenocarcinoma
Circulating Tumor DNA as a Novel Biomarker for Pancreatic Cancer
PDAC Subtypes/Stratification
Circulating Tumor Cells as Biomarkers in Pancreatic Cancer
Personalized Models of Human PDAC
Therapeutic Targeting of Stromal Components
Epigenetic Targeting
Targeting Metabolism
Targeting the Immune System in Pancreatic Cancer

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Tags: Translational Pancreatic, Cancer Research, Understanding, Mechanisms, Novel Clinical Trials, Christoph Michalski, Jonas Rosendahl, Patrick Michl, Jörg Kleeff