Traumatic Brain Injury Rehabilitation Treatment and Case Management Fourth Edition by Mark 1315354179 9781315354170

Traumatic Brain Injury Rehabilitation Treatment and Case Management Fourth Edition by Mark Ashley – Ebook Instant Download/Delivery ISBN(s): 1315354179, 9781315354170

Product details:

• ISBN 10: 1315354179
• ISBN 13: 9781315354170
• Author: Mark

The fourth edition of this text constitutes a continuation of 20 years of coverage of traumatic brain injury, and broadens the discussion of acquired brain injury. Within TBI, the paradigm shift from an injury occurring at a point in time to a disease entity of a chronic nature is changing the discussion of diagnosis, management, treatment and outcome assessment. Disease specification that differentiates TBIs by the mechanism of injury, the exact nature of the injury, the extent of injury, presence of co-morbidities and their exact nature, gender, age, race, and genome are emerging as crucial. Disease differentiation has impacted diagnosis, treatment and outcome.

Table of contents:

Part 1 Neuroscience

Chapter 1 Bioscience indications for chronic disease management and neuromedical interventions following traumatic brain injury

Introduction

Loss of Axonal Integrity After TBI

Blood–Brain Barrier

Microglia

Cerebral inflammation is mediated by microglia

Microglial alterations following TBI

Inflammation and axonal damage

The dual action of microglia and cytokines

Mitochondria

Myelination

Neuroendocrine function

Somatotrophic axis

Gonadotroph axis

Testosterone

Estrogen

Progesterone

Thyrotroph axis

Clinical implications and potential therapeutics

References

Chapter 2 The neurobiology of traumatic brain injury

Introduction

What happens to the cells in the brain following TBI?

Outcome measurements in experimental animal models

Long-term issues with TBI

Experimental animal models of CTE as defined by phosphorylated tau

Summary and conclusions

References

Chapter 3 Repeat traumatic brain injury models

Introduction

The models

Experimental design

Repeat mild TBI in developing animal models

Adolescent RTBI

Histology and behavior

Brain impact interval influences metabolism and amyloid deposition

Pituitary dysfunction

Gender

Chronic pathology

Prepubertal repeat TBI

Characterization of pathology time course

Repeat mild TBI in adult animal models

Metabolism

Inflammation

Axonal injury

Acute and chronic behavioral profiles

Neurodegenerative diseases

Summary

References

Chapter 4 Neuroplasticity and rehabilitation therapy

Introduction

Habituation

Sensitization

Types of learning

Hierarchical learning

Multimodal rehabilitation

Neurogenesis in adult humans

Constraint-induced therapy

Summary

References

Chapter 5 Environmental enrichment: A preclinical model of neurorehabilitation for traumatic brain injury

Traumatic brain injury is a significant health care issue

EE defined

EE as a potential therapeutic approach: early support

EE as a potential therapeutic approach: further support

Benefits of EE are not gender dependent

Benefits of EE are enduring

Therapeutic window of EE is flexible

EE: combination therapy paradigms

Potential mechanisms mediating EE-induced benefits

Caveats to the EE effect

Conclusion

Acknowledgments

References

Chapter 6 Neuroanatomy of basic cognitive function

Introduction

Sensory systems

Reticular Formation

Hypothalamus, pituitary, thalamus, and basal ganglia

Hypothalamus and Pituitary

Thalamus

Basal Ganglia

Medial Temporal Lobe and Hippocampal Complex

Inferior Temporal Lobe

Frontal Lobe

Commissural and Association Tract Fibers

Principles of Neurophysiology and Cognition

Information Processing, Neurotransmission, and Learning

Neuromodulatory neurotransmitters

Networks and Cognitive Function

Specific functions

Working Memory

Decision-Making

Perceptual Decision-Making

Prospective Memory

Default mode network

DMN: Hubs and subsytems

DMN functional significance

Frontoparietal attention networks

Summary

References

Chapter 7 TBI rehabilitation: Lessons learned from animal studies about mechanisms, timing, and combinatorial approaches

Introduction

Rehabilitation promotes recovery of function and plasticity

Rehabilitation and plasticity following TBI

Rehabilitation Timing

Combining rehabilitation with adjunctive therapies: What’s the winning combination?

Conclusions and future directions

References

Chapter 8 Diet and exercise interventions to promote metabolic homeostasis in TBI pathology

Introduction

Lifestyle and Mental Health

The Metabolic Pathology of TBI

BDNF: A Link Between Metabolic and Cognitive Dysfunctions in the Pathology of TBI

Role of Nutritional Factors in Normal Brain Health And After TBI

Omega-3 fatty acids

Plasma membrane is susceptible to the effects of TBI and diet

The Antioxidant Action of Vitamin E on TBI

Dietary Polyphenols and Cognitive Performance: Curcuminoids

Dietary Polyphenols and Cognitive Performance: Resveratrol

Dietary Flavonoids and Cognitive Function

Metabolic disturbances as a signature of TBI pathology

Diet and Epigenetics: A Platform for Extending Action and Influencing Neurological Disorders

Effect of Exercise on Brain Health and Repair

Collaborative Effects of Diet and Exercise

Conclusion

References

Chapter 9 Disruptions in physical substrates of vision following traumatic brain injury

Introduction

Vision

General anatomy

Core components

Anatomic components

Cortical organization

Neocortical modules

Neural networks

Anatomical divisions of visual system

Image system

Optical system

Primary visual system

Optic radiation

Secondary visual system

Nonimage system

Retinohypothalamic tract

Principles of visual system organization

Functional component of the visual system

Reception

Primary Visual System

Oculomotor system

Attention

Arousal/alerting

Orienting network

Selective attention network

Higher visual processing

Ventral stream

Dorsal stream

Beyond the ventral/dorsal stream

TBI

Definition

Primary effect

Secondary effects

Classifications of visual deficit

Receptive system

Attention system

Higher visual processing system

Summary

References

Chapter 10 Potential utility of resting state fMRI–determined functional connectivity to guide neurorehabilitation

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