Understanding Pulmonary Pathology Applying Pathological Findings in Therapeutic Decision Making 1st Edition by Richard L Kradin ISBN 0128013044 978-0128013045

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ISBN 10: 0128013044 

ISBN 13: 978-0128013045

Author: Richard L. Kradin

Understanding Pulmonary Pathology: Applying Pathological Findings in Therapeutic Decision Making provides a much needed reference tool for pathologists, practicing pulmonologists, and pulmonologist researchers. The unique approach to pulmonary pathology combines the multi-perspective views of the author who was trained formally as both a pulmonologist and as a pathologist.

The book addresses what is often lost in translation when conveying the experience of pulmonary pathology in practicing pulmonary medicine. This important tool conveys detailed information concerning the anatomic basis of disease to those oriented towards thinking about diseases physiologically, providing the opportunity for optimal diagnosis, treatment of patients, and advancement of research.

Table of contents: 

Chapter 1. Approach to the Sampling of the Lung

1. Handling of the Samples
2. Histochemical Stains
3. Immunostains

Chapter 2. Anatomy of the Lung

1. Gross Pulmonary Anatomy
2. Airway Anatomy
3. Pulmonary Vessels
4. Bronchial Circulation
5. Pulmonary Lymphatics
6. The Elastic Structure of the Lungs
7. Pleura
8. Pulmonary Vascular Elastic Fibers
9. Immune Anatomy

Chapter 3. Pulmonary Responses to Injury

1. Acute Inflammation
2. Chronic Inflammation
3. Fibrosis
4. Histiocytic (Macrophage) Reactions
5. The Airway Wall
6. The Alveolar Interstitium
7. Pulmonary Vessels
8. Pleura

Chapter 4. The Radiographic Patterns of Common Lung Diseases

1. Introduction
2. Airway Diseases
3. Small Airways Disease
4. Direct Signs
5. Indirect Signs
6. Infection
7. Diffuse Lung Disease
8. Lung Neoplasia

Chapter 5. Diseases of the Airways

1. Asthma
2. Chronic Obstructive Pulmonary Disease
3. Chronic Bronchitis
4. Emphysema
5. Exacerbations of COPD
6. Bronchiectasis
7. Cystic Fibrosis
8. The Small Airways
9. Obliterative Bronchiolitis
10. Bronchiolitis Obliterans Organizing Pneumonia
11. Follicular Bronchiolitis
12. Diseases of the Upper Airways
13. Tracheal Stenosis
14. Other Tracheobronchial Disorders
15. Relapsing Polychondritis
16. Tracheopathia Osteoplastica
17. Tracheobronchomalacia

Chapter 6. Interstitial Lung Disease

1. Usual Interstitial Pneumonitis
2. Management
3. Nonspecific Interstitial Pneumonitis
4. Lymphocytic Interstitial Pneumonitis
5. Hypersensitivity Pneumonitis
6. Diffuse Alveolar Damage/Acute Interstitial Pneumonia
7. Acute Interstitial Pneumonia
8. Diffuse Alveolar Injury With Delayed Alveolar Re-Epithelialization
9. Other Poorly Defined Entities
10. Sarcoidosis
11. Granulolymphocytic Interstitial Lung Disease
12. Pleuro-Pulmonary Fibroelastosis
13. IgG4-Mediated Lung Disease

Chapter 7. Nonneoplastic Smoking-Related Disorders

1. Respiratory Bronchiolitis (Interstitial Lung Disease)
2. Desquamative Interstitial Pneumonitis
3. LCH (or Eosinophilic Granuloma)
4. Smoking-Related Interstitial Fibrosis

Chapter 8. Pulmonary Vascular Disorders

1. Pulmonary Arterial Hypertension
2. Idiopathic Pulmonary Arterial Hypertension
3. Pulmonary Veno-occlusive Disease
4. Pulmonary Capillary Hemangiomatosis
5. Other Causes of Pulmonary Vascular Disease
6. Pulmonary Thromboembolic Disease
7. Chronic Thromboembolic Pulmonary Hypertension
8. Other Forms of Pulmonary Thromboembolic Disease
9. Tumor Emboli
10. Pulmonary Angiitis
11. GPA—Wegener’s Granulomatosis
12. Pulmonary Alveolar Hemorrhage Syndromes
13. Antialveolar Basement Membrane Disease or Goodpasture’s Disease
14. Drug-Induced Angiitis
15. Arteriovenous Malformations

Chapter 9. Pulmonary Infection

1. The Approach to Sampling for Infection
2. Transbronchial Biopsy
3. Fine Needle Aspiration Biopsy
4. Transbronchial Needle Aspiration Biopsy
5. Video-Assisted and Open Thoracoscopic Biopsy
6. Handling Lung Biopsies
7. Pulmonary Injury in Infection
8. RNA Viruses
9. DNA Viruses
10. Other “Atypical Pneumonias”
11. Protozoa
12. Nematodes (Round Worms)
13. Microbes Associated With Bioterrorism

Chapter 10. Lung Cancer

1. Squamous Cell Carcinoma
2. Small-Cell and Large-Cell (Neuroendocrine) Carcinoma
3. Adenocarcinoma
4. Multiple Tumors
5. Molecular Analysis
6. Immunohistology
7. Large-Cell Undifferentiated Carcinoma
8. Pleomorphic Carcinomas
9. Malignant Melanoma
10. Metastatic Carcinoma
11. Sarcomas of the Lung
12. Tumors of Intermediate Malignant Potential
13. Salivary Gland Tumors
14. Mucoepidermoid Tumors
15. Adenoid Cystic Carcinoma
16. Mixed Tumors
17. Benign Tumors
18. Sclerosing Hemangioma
19. Benign Clear Cell “Sugar” Tumor (Perivascular Cell Tumor)
20. Glomus Tumors
21. Squamous Papillomas
22. Alveolar and Papillary Adenoma
23. Benign Tumorlets

Chapter 11. Lymphoid Lesions

1. Benign Intrapulmonary Lymph Nodes
2. Nodular Lymphoid Hyperplasia
3. Lymphoid Interstitial Pneumonitis
4. Lymphomatoid Granulomatosis
5. Extranodal Marginal Zone B-Cell Lymphoma (MALT Lymphoma)
6. Primary B-Cell Lymphoma
7. Hodgkin’s Lymphoma
8. Intravascular Large B-Cell Lymphoma
9. T-Cell Lymphoma
10. Leukemia

Chapter 12. Iatrogenic Lung Diseases

1. Drug-Induced Pneumonitis
2. Opiate-Induced Changes
3. Amiodarone
4. Methotrexate
5. Mesalamine
6. Sulfonamides
7. Cytotoxic Drugs
8. Radiation
9. Nitrofurantoin
10. Transfusion-Related Acute Lung Injury
11. Newer Drugs

Chapter 13. Toxic Exposures

1. Toxic Gases
2. Asbestos
3. Asbestos-Related Cancer
4. Talcosis
5. Silicosis
6. Silicatosis
7. Coal Worker’s Pneumoconiosis
8. Hard Metal Pneumoconiosis
9. Beryllium Disease
10. Siderosis
11. Aluminosis

Chapter 14. Sundry Disorders

1. Pulmonary Edema
2. Dendriform Ossification
3. Alveolar Microlithiasis
4. Dystrophic Calcification
5. Aspiration Pneumonia
6. Food
7. Lipid Aspiration
8. Cocaine Inhalation (“Crack”)
9. Amyloidosis
10. Hyalinizing Granuloma
11. Pulmonary Alveolar Lipoproteinosis
12. Pulmonary Scars
13. Lymphangioleiomyomatosis
14. Chronic Eosinophilic Pneumonia

Chapter 15. Pulmonary Transplant Pathology

1. Acute Allograft Rejection
2. Airways Inflammation
3. Chronic Graft Airway Rejection
4. Chronic Vascular Rejection
5. Humoral Rejection
6. Other Forms of Graft Injury
7. Postimplantation Response
8. Aspiration
9. Posttransplant Lymphoproliferative Disorder
10. Recurrence of Disease in an Allograft

Chapter 16. Pediatric Lung Disease

1. Hyaline Membrane Disease
2. Sequestrations
3. Intralobar Sequestration
4. Bronchial Atresia and Congenital Cystic Adenomatoid Malformation
5. Neuroendocrine Hyperplasia of Childhood
6. Interstitial Lung Diseases
7. Surfactant Protein Deficiency
8. ABCA3 Deficiency
9. Surfactant-Protein C Deficiency
10. Malignant Tumors

Chapter 17. Pleural Diseases

1. Reactive Fibrinous Pleuritis
2. Pleural Plaques
3. Benign Tumors of the Pleura
4. Desmoid Tumors
5. Neural Tumors
6. Metastatic Pleural Tumors
7. Malignant Mesothelioma
8. Rare Pleural Malignancies

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