Water insoluble drug formulation Third Edition Liu 1351646826 9781351646826
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Product details:
- ISBN 10: 1351646826
- ISBN 13: 9781351646826
- Author: Liu
Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development.
Table of contents:
Chapter 1 Introduction
Chapter 2 Solubility Theory
Chapter 3 Prediction of Solubility
Chapter 4 Preformulation Aspects of Insoluble Compounds
Chapter 5 Water-Insoluble Drugs and Their Pharmacokinetic Behaviors
Chapter 6 Regulatory Aspects of Dissolution for Low Solubility Drug Products
Chapter 7 Formulation Strategies and Practice Used for Drug Candidates with Water-Insoluble Properties for Toxicology, Biology, and Pharmacology Studies in Discovery Support
Chapter 8 Application of Complexation in Drug Development for Insoluble Compounds
Chapter 9 Solubilization Using Cosolvent Approach
Chapter 10 Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and Delivery—Part I: Parenteral Applications
Chapter 11 Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and Delivery—Part II: Oral Applications
Chapter 12 Micellization and Drug Solubility Enhancement
Chapter 13 Polymeric Micelles in Water-Insoluble Drug Delivery
Chapter 14 Liposomes in Solubilization
Chapter 15 Pharmaceutical Salts
Chapter 16 Prodrugs for Improved Solubility in Water
Chapter 17 Particle Size Reduction
Chapter 18 Development of Solid Dispersion for Poorly Water-Soluble Drugs
Chapter 19 Alteration of the Solid State of the Drug Substances: Polymorphs, Solvates, and Amorphous Forms
Chapter 20 Pharmaceutical Powder Technology—ICH Q8 and Building the Pyramid of Knowledge
Chapter 21 Soft Gelatin Capsules Development
Chapter 22 Oral Modified-Release Drug Delivery for Water-Insoluble Drugs
Chapter 23 Scalable Manufacturing of Water-Insoluble Drug Products
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